Can I change employers on a German skilled worker visa?

A skilled worker residence permit is granted on the basis of qualified employment, so it is connected to working in a job that matches your qualifications. That does not lock you to a single employer forever, but a job change is not automatic.

When moving to a new employer, make sure the new role is still qualified employment that fits your recognised qualification, and follow any notification or approval steps required for your permit type. Checking before you resign helps you avoid a gap in your right to work.