
Yes. You generally must secure the relevant business authorisation and any professional registrations before your residence application, because the authorities assess whether you may lawfully carry out the activity.
Luxembourg expects self-employed third-country nationals to hold the prerequisite professional access to their intended activity. For regulated professions such as physicians, dentists, pharmacists and veterinarians, you must meet the specific legal conditions, and many trades and commercial activities require a business permit from the competent authority.
Your file is reviewed against the qualifications and authorisations needed for the precise activity you plan to run. It is sensible to confirm what your activity requires and to gather the registrations or accreditations before lodging the temporary authorisation request, since missing approvals will hold up or sink the application.
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