What medical and police checks are required for a PNP permanent residence application?

A provincial nomination does not replace federal admissibility checks. Every applicant for permanent residence, including PNP applicants, is assessed against federal standards for medical, criminal and security admissibility.

In practice this means completing an immigration medical exam with an approved panel physician and providing police certificates from countries where you have lived. These requirements also apply to accompanying family members. Being found inadmissible on medical or criminal grounds can stop a permanent residence application even when you hold a valid nomination.