
Yes. You must be a national of a country that maintains a qualifying treaty of commerce and navigation with the United States, and the business must share that nationality.
The E-2 category is only open to nationals of countries that have the relevant treaty with the US. Your individual nationality is what matters, not where you currently live, and the investing enterprise must be at least 50 percent owned by nationals of the same treaty country.
If your country of citizenship is not on the treaty list, you cannot use the E-2 even with a large investment. Some applicants acquire a second nationality from a treaty country to qualify, but the nationality must be genuine. Always confirm your country's current treaty status, because the list and the conditions attached to each treaty can change.
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